Fuciskin C Cream
Topical steroids with anti-infectives such as Fuciskin C (Clobetasol Propionate & Fusidic Acid Cream) are combination creams that contain both a steroid and an anti-infective agent and are used to treat infections of the skin or scalp that are red, itchy, or have minor swelling. Steroids (also known as corticosteroids) are very effective at reducing inflammation (redness and swelling), suppressing the immune system, and constricting (narrowing) blood vessels in the skin. They are available in various potencies (strengths).
Anti-infective agents kill or inhibit the spread of infectious organisms. They include antibiotics (kill bacteria), antibacterials (suppress bacterial growth), antifungal (kill or suppress fungi) and antiviral (kill or suppress viruses) agents.
Fuciskin C cream is used to help reduce the redness and itchiness of certain skin problems such as eczema, psoriasis, lichen planus, discoid lupus erythematosus, dermatitis and other skin conditions. It is used to treat conditions where the skin is infected by germs (bacteria), such as impetigo
Adults and children:
Uncovered lesions: apply gently three or four times daily; Covered lesions: less frequent applications may be adequate.
Mechanism of Action
Fusidic acid belongs to a unique group of antibiotics. These fusidanes act to inhibit bacterial protein synthesis by blocking the lengthening of factor G. This is to prevent it from associating with ribosomes and GTP, thus preventing energy supply to the synthesis process.
Clobesterol propionate controls the biosynthesis of prostaglandins and leukotrienes, inhibiting the release of their common precursor arachidonic acid. It bind to the glucocorticoid receptor, which complexes, enters the cell nucleus and modifies genetic transcription (transrepression/transactivation).
Fusidic acid is excreted mainly in the bile with little excreted in the urine. Inactive metabolites of Clobesterol are excreted by the kidneys. Small amounts of the metabolites also are excreted in feces.
In Vitro studies show that fusidic acid can penetrate intact human skin. The degree of penetration depends on factors such as the duration of exposure to fusidic acid and the condition of the skin.
Amount of clobesterol absorbed depends on the potency of the preparation, the amount applied, and the nature of the skin at the application site. It ranges from about 1% to as high as 36% .
Absorption increases in areas of skin damage, inflammation, or occlusion. Some systemic absorption of topical corticosteroids occurs, especially through the oral mucosa.
Hypersensitivity, dermatitis and rash are the most common side effect. A very serious allergic reaction to this drug is rare.
No drug interactions have been identified
No effects during pregnancy are anticipated, since systemic exposure to topically applied fusidic acid/sodium fusidate is negligible. Topical fusidic acid 20mg/g cream can be used during pregnancy.
No effects on the breastfed new-born/infant are anticipated since the systemic exposure of the breast-feeding woman is negligible. Fuciskin cream can be used during breast-feeding but it is recommended to avoid applying iton the breast.
Hypersensitivity to the active substance is rare. No drug interactions have been identified.